ABSTRACT
Coronaviruses (CoVs) are RNA viruses threatened the global health. The causative microorganism, causing coronavirus disease-2019 (COVID-19), is known as (novel coronavirus) or (severe acute respiratory syndrome coronavirus-2) (SARS-CoV-2). Furthermore, respiratory illnesses such as pneumonia and breathing failure are caused by COVID-19, first reported in Wuhan, China. So far, over 939,968COVID-19 death cases out of approximately 29,765,666 confirmed cases have been globally reported.However, global research institutions and companies have exerted tremendous effort to develop vaccines and drugs against SARS-CoV-2. Finally, our aim is to comprehensively review epidemiology, etiology, pathophysiology as well as the outlined the several strategies (preclinical/clinical) of COVID-19 treatment at the molecular level.